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Curr Opin Microbiol. 2010 Aug;13(4):480-90. doi: 10.1016/j.mib.2010.05.014. Epub 2010 Jun 25.

Life with eight flagella: flagellar assembly and division in Giardia.

Author information

1
Department of Microbiology, One Shields Avenue, UC Davis, Davis, CA 95616, USA. scdawson@ucdavis.edu

Abstract

Flagellar movement in Giardia, a common intestinal parasitic protist, is crucial to its survival in the host. Each axoneme is unique in possessing a long, cytoplasmic portion as well as a membrane-bound portion. Intraflagellar transport (IFT) is required for the assembly of membrane-bound regions, yet the cytoplasmic regions may be assembled by IFT-independent mechanisms. Steady-state axoneme length is maintained by IFT and by intrinsic and active microtubule dynamics. Following mitosis and before their segregation, giardial flagella undergo a multigenerational division cycle in which the parental eight flagella migrate and reposition to different cellular locations; eight new flagella are assembled de novo. Each daughter cell thus inherits four mature and four newly synthesized flagella.

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PMID:
20580308
PMCID:
PMC4927303
DOI:
10.1016/j.mib.2010.05.014
[Indexed for MEDLINE]
Free PMC Article

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