Format

Send to

Choose Destination
Curr Opin Biotechnol. 2010 Oct;21(5):592-8. doi: 10.1016/j.copbio.2010.05.009. Epub 2010 Jun 25.

How apicomplexan parasites move in and out of cells.

Author information

1
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA. sibley@borci.wustl.edu

Abstract

Apicomplexan parasites utilize a unique form of 'gliding motility' to traverse across substrates, migrate through tissues, and invade into and finally egress from their vertebrate host cells. Parasite gliding relies on the treadmilling of surface adhesins linked to short actin filaments that are translocated rearward by stationary small myosin motors. New details reveal mechanistic insight into the coordinated release and processing of adhesins, the complexity of adhesin-substrate interactions, the regulation of the actin-myosin motor complex, and the formation of a novel junction at the host-parasite interface. These activities are carefully orchestrated to provide an efficient process for motility that is essential for parasite survival. The parasite-specific nature of many of these steps reveals several essential points that may be targeted for intervention.

PMID:
20580218
PMCID:
PMC2947570
DOI:
10.1016/j.copbio.2010.05.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center