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FEBS Lett. 2010 Sep 10;584(17):3773-8. doi: 10.1016/j.febslet.2010.06.016. Epub 2010 Jun 19.

Defending the end zone: studying the players involved in protecting chromosome ends.

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1
Department of Genetics, The MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the "end zone" of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres.

PMID:
20579983
PMCID:
PMC3657741
DOI:
10.1016/j.febslet.2010.06.016
[Indexed for MEDLINE]
Free PMC Article
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