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Clin Infect Dis. 2010 Aug 1;51(3):e24-7. doi: 10.1086/654801.

Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.

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1
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA. jqd6@cdc.gov

Abstract

Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.

PMID:
20578874
DOI:
10.1086/654801
[Indexed for MEDLINE]
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