Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Aging Neurosci. 2010 Jun 3;2:22. doi: 10.3389/fnagi.2010.00022. eCollection 2010.

Microglial activation and neuroinflammation in Alzheimer's disease: a critical examination of recent history.

Author information

1
Department of Neuroscience, University of Florida College of Medicine Gainesville, FL, USA.

Abstract

The neurofibrillary degeneration that occurs in Alzheimer's disease (AD) is thought to be the result of a chronic and damaging neuroinflammatory response mediated by neurotoxic substances produced by activated microglial cells. This neuroinflammation hypothesis of AD pathogenesis has led to numerous clinical trials with anti-inflammatory drugs, none of which have shown clear benefits for slowing or preventing disease onset and progression. In this paper, I make the point that AD is not an inflammatory condition, and reconstruct the sequence of events during the 1980s and 1990s that I believe led to the development of this faulty theory.

KEYWORDS:

aging; amyloid; chronic inflammation; cytokines; major histocompatibility complex antigens

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center