Format

Send to

Choose Destination
Trends Immunol. 2010 Jul;31(7):260-9. doi: 10.1016/j.it.2010.05.005. Epub 2010 Jun 25.

FADD: a regulator of life and death.

Author information

1
Inserm, U1016, Institut Cochin, Département d'Immunologie-Hématologie, Paris, France. lea.remy-tourneur@parisdescartes.fr

Abstract

FAS-associated protein with death domain (FADD) is the key adaptor protein transmitting apoptotic signals mediated by the main death receptors (DRs). Besides being an essential instrument in cell death, FADD is also implicated in proliferation, cell cycle progression, tumor development, inflammation, innate immunity, and autophagy. Recently, many of these new functions of FADD were shown to be independent of DRs. Moreover, FADD function is dictated by protein localization and phosphorylation state. Thus, FADD is a crucial and unique controller of many essential cellular processes. The full understanding of the networks dictating the ultimate function of FADD may provide a new paradigm for other multifaceted proteins.

PMID:
20576468
DOI:
10.1016/j.it.2010.05.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center