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J Vasc Surg. 2010 Sep;52(3):723-9. doi: 10.1016/j.jvs.2010.04.020. Epub 2010 Jun 23.

Upper extremity ischemia treated with tissue repair cells from adult bone marrow.

Author information

1
Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio 43606, USA. marilyn.gravett@promedica.org

Abstract

BACKGROUND:

Unreconstructable critical ischemia with gangrene of the upper extremity is rarely due to atherosclerosis alone, and few treatment options exist. We describe a patient with gangrene of both hands as a result of unreconstructable atherosclerotic disease of both upper extremities who was successfully treated with tissue repair cells (TRCs) produced from the patient's bone marrow.

METHODS:

A patient with type 1 diabetes was referred with bilateral upper extremity digital gangrene due to unreconstructable forearm and hand atherosclerosis. He was evaluated for therapeutic angiogenesis using TRCs.

RESULTS:

Following the intramuscular injection of TRCs produced from autologous bone marrow stem cells, the patient demonstrated improved arterial perfusion and a durable clinical response with healing of all amputation sites and cessation of pain.

CONCLUSIONS:

The production of TRCs results in the expansion of stem and early progenitor cells, including CD90+ mesenchymal cells and endothelial progenitor cells. This is the first reported case of end-stage upper extremity ischemia treated with TRCs harvested from adult bone marrow.

PMID:
20576396
DOI:
10.1016/j.jvs.2010.04.020
[Indexed for MEDLINE]
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