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Congenit Heart Dis. 2010 May-Jun;5(3):303-8. doi: 10.1111/j.1747-0803.2009.00344.x.

Development of factor V and thrombin inhibitors in children following bovine thrombin exposure during cardiac surgery: a report of three cases.

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Department of Pediatrics, Hematology-Oncology Section, Baylor College of Medicine, Houston, TX 77030, USA.


Factor V and thrombin inhibitors may develop following exposure to bovine thrombin preparations. In patient populations where exposure to bovine thrombin is common, such as children undergoing cardiovascular surgery, the development of such inhibitors should be considered in the evaluation of prolonged prothrombin times. We present three cases of children developing factor V and thrombin inhibitors following repeated exposure during cardiac surgical procedures.

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