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Zhong Yao Cai. 2010 Feb;33(2):246-9.

[Comparison of pharmacokinetics about ermiao capsules and ermiao pellet].

[Article in Chinese]

Author information

1
Liaoning University of TCM, Dalian 116600, China. zhouling0824@126.com

Abstract

OBJECTIVE:

To compare the pharmacokinetics about Ermiao capsules and ermiao pellet, and observe the changes in plasma concentration with different formulations in animals from the perspective of pharmacokinetics.

METHODS:

After the rabbits were administered with Ermiao capsules and ermiao pellet through ig. HPLC was used to determine berberine in blood plasma at different times, DAS 2.0 procedure was used to process concentration-time data.

RESULTS:

In the rabbit plasma samples,the linear range of berberine was 0.00427-0.427 microg/mL, it has a high extract recovery rate,and day-day precision RSD was less than 10%. The whole blood concentration-time course of berberine in Ermiao capsules was fitted to be a two-compartment model, and berberine in Ermiao pellet was fitted to be a one-compartment model.

CONCLUSION:

This essay establishes a method for determine berberine in rabbit plasma, provided the pharma cokinetic parameters for rational administration of ermiao capsules, and also provided the pharmacokinetic study method of compounds.

PMID:
20575422
[Indexed for MEDLINE]
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