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J Neurosci. 2010 Jun 23;30(25):8519-28. doi: 10.1523/JNEUROSCI.4837-09.2010.

Prefrontal cortex activity during flexible categorization.

Author information

1
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Abstract

Items are categorized differently depending on the behavioral context. For instance, a lion can be categorized as an African animal or a type of cat. We recorded lateral prefrontal cortex (PFC) neural activity while monkeys switched between categorizing the same image set along two different category schemes with orthogonal boundaries. We found that each category scheme was largely represented by independent PFC neuronal populations and that activity reflecting a category distinction was weaker, but not absent, when that category was irrelevant. We suggest that the PFC represents competing category representations independently to reduce interference between them.

PMID:
20573899
PMCID:
PMC3709835
DOI:
10.1523/JNEUROSCI.4837-09.2010
[Indexed for MEDLINE]
Free PMC Article

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