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Diabetes Care. 2010 Sep;33(9):1957-9. doi: 10.2337/dc10-0547. Epub 2010 Jun 23.

Effects of weight loss among metabolically healthy obese men and women.

Author information

1
School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.

Abstract

OBJECTIVE:

Weight loss among metabolically healthy obese (MHO) individuals may be unnecessary or result in elevated cardio-metabolic risk. We studied the effects of exercise- or diet-induced weight loss on cardio-metabolic risk among MHO and metabolically abnormal obese (MAO) adults.

RESEARCH DESIGN AND METHODS:

Participants were 63 MHO and 43 MAO adults who took part in 3 to 6 months of exercise- or diet-induced weight loss intervention. Changes in anthropometry, adipose tissue distribution, and cardio-metabolic risk factors were assessed.

RESULTS:

Body weight, waist circumference, and total abdominal and visceral adipose tissue were reduced in all subjects (P < 0.05). Improvements in insulin sensitivity were observed in MHO and MAO men and women (P < 0.05), but were greater in the MAO individuals (P < 0.05). Fasting insulin was the only other cardio-metabolic improvement among MHO individuals (P < 0.05).

CONCLUSIONS:

Lifestyle-induced weight loss among MHO subjects is associated with a reduction in total and abdominal obesity and improvement in selected cardio-metabolic risk factors.

PMID:
20573755
PMCID:
PMC2928342
DOI:
10.2337/dc10-0547
[Indexed for MEDLINE]
Free PMC Article

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