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Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a000687. doi: 10.1101/cshperspect.a000687. Epub 2010 Jun 23.

Paraspeckles.

Author information

  • 1Western Australian Institute for Medical Research and Centre For Medical Research, University of Western Australia, Crawley, 6009 Western Australia, Australia. archafox@waimr.uwa.edu.au

Abstract

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.

PMID:
20573717
PMCID:
PMC2890200
DOI:
10.1101/cshperspect.a000687
[PubMed - indexed for MEDLINE]
Free PMC Article
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