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Bioorg Med Chem Lett. 2010 Aug 1;20(15):4566-8. doi: 10.1016/j.bmcl.2010.06.018. Epub 2010 Jun 8.

A specific and direct comparison of the trifluoromethyl and pentafluoro sulfanyl groups on the selective dopamine D(3) antagonist 3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-phenyl-3-azabicyclo[3.1.0]hexane template.

Author information

1
Neurosciences Centre of Excellence, GlaxoSmithKline Medicines Research Centre, Verona, Italy. fm20244@gsk.com

Abstract

A direct and specific comparison of a trifluoromethyl group with the corresponding pentafluorosulfanyl group is made in terms of primary affinity and pharmacokinetic properties.

PMID:
20573506
DOI:
10.1016/j.bmcl.2010.06.018
[Indexed for MEDLINE]

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