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Int Urogynecol J. 2010 Nov;21(11):1359-64. doi: 10.1007/s00192-010-1211-4. Epub 2010 Jun 23.

Long-term outcome of transurethral injection of hyaluronic acid/dextranomer (NASHA/Dx gel) for the treatment of stress urinary incontinence (SUI).

Author information

1
Department of Obstetrics and Gynaecology, Mayday University Hospital, 530 London Road, Croydon CR7 7YE, Surrey.

Abstract

INTRODUCTION AND HYPOTHESIS:

To investigate the long-term safety and efficacy of transurethral injection of NASHA/Dx gel in women suffering from stress urinary incontinence (SUI).

METHODS:

Women with SUI treated with NASHA/Dx gel via the transurethral Implacer device at Mayday University Hospital between November 2002 and December 2003 had long-term outcomes of therapy evaluated.

RESULTS:

Eighteen of 21 were followed-up at mean 6.7 years (±SD 0.15). One year after the injection, 11/21 (52.3%) reported improvement. Of the women, 6/21 (28.5%) had a repeat injection and seven (33.3%) women experienced adverse events in the form of periurethral swellings. At 6.7 years, only one of seven women was continent of urine without requiring any further continence procedure, 44.4% were still experiencing SUI symptoms. Nine of 18 (42.8%) had undergone other continence procedures.

CONCLUSION:

Transurethral injection of NASHA/Dx gel in women with SUI is associated with complications and not effective in the long term.

PMID:
20571764
DOI:
10.1007/s00192-010-1211-4
[Indexed for MEDLINE]

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