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Nat Rev Mol Cell Biol. 2010 Jul;11(7):502-14. doi: 10.1038/nrm2927.

Adherens junctions: from molecules to morphogenesis.

Author information

1
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada. tony.harris@utoronto.ca

Abstract

How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin-catenin complexes at their core are therefore the subjects of intense research. Recent work has greatly advanced our understanding of the molecular organization of AJs and how cadherin-catenin complexes engage actin, microtubules and the endocytic machinery. As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis.

PMID:
20571587
DOI:
10.1038/nrm2927
[Indexed for MEDLINE]

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