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Clin Neuropharmacol. 2010 Jul;33(4):204-6. doi: 10.1097/WNF.0b013e3181e29174.

Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature.

Author information

1
Outpatient Clinic for Adult ADHD, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR Clinic Essen; and daggerDepartment of Neurology, Alfried Krupp Hospital Essen, Essen, Germany. markus.kraemer@krupp-krankenhaus.de

Abstract

OBJECTIVE:

We present 3 new cases of psychotic symptoms in patients with adult attention-deficit/hyperactivity disorder while regularly treated with a stimulant therapy with methylphenidate.

METHODS:

Existing literature about this theme is reviewed, and potential mechanisms are discussed.

RESULTS AND CONCLUSIONS:

Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a careful and regular psychiatric monitoring is essential in all patients treated with methylphenidate.

PMID:
20571380
DOI:
10.1097/WNF.0b013e3181e29174
[Indexed for MEDLINE]

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