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J Affect Disord. 2010 Dec;127(1-3):130-8. doi: 10.1016/j.jad.2010.04.031. Epub 2010 May 31.

Childhood adversities, adulthood life events and depression.

Author information

1
Department of Psychiatry, University of Turku, Satakunta Hospital District, Finland. jyrki.korkeila@utu.fi

Abstract

BACKGROUND:

The role of childhood adversities in predicting adulthood depression has been suggested to be complex and in need of additional comprehensive studies.

AIMS:

This investigation set out to examine whether increased exposure to life events (LEs) in adulthood mediates the association between childhood adversities and adulthood depression.

METHODS:

This study is based on a random health survey sample from the Finnish working-aged population (n=16,877) with a follow-up of up to 7 years. Depression was identified by Beck Depression Inventory, records of antidepressant prescriptions and hospitalization due to depression obtained from national health registers.

RESULTS:

Childhood adversities were associated with an increased likelihood of experiencing a high number of LEs in adulthood and their perceived burdensomeness. The mean number of new LEs correlated significantly (P<0.001) in a dose-response relationship with the number of childhood adversities. Reporting childhood adversities was associated with a 1.28-2.70-fold increase in the odds of depression as indicated by BDI score, a 1.29-1.94-fold increase in the rate of antidepressant prescriptions and a 1.17-4.04-fold increase in the risk of hospitalization due to depression. Adjustment for new LE attenuated these associations by 21-24%, but did not render them insignificant.

CONCLUSIONS:

Increased exposure to adult negative life events proximal to adult depression may partially explain the association between childhood adversities and adult depression.

PMID:
20569993
DOI:
10.1016/j.jad.2010.04.031
[Indexed for MEDLINE]

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