Format

Send to

Choose Destination
J Am Chem Soc. 2010 Jul 21;132(28):9540-2. doi: 10.1021/ja102595j.

UV and near-IR triggered release from polymeric nanoparticles.

Author information

1
School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, University of California at San Diego, La Jolla, California 92093, USA.

Abstract

A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model pharmaceutical Nile Red. Triggered burst release of the payload upon irradiation and subsequent degradation of the nanoparticles were observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.

PMID:
20568765
PMCID:
PMC2945686
DOI:
10.1021/ja102595j
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center