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AIDS. 2010 Jun 1;24(9):1374-7.

Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to- child HIV transmission.

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Gertrude H. Sergievsky Center, Department of Epidemiology, Columbia University, New York, New York, USA.


We reviewed the potential impact of new WHO criteria for antiretroviral therapy using data from 1025 HIV-infected women and infants followed for 24 months in Lusaka, Zambia. The new criteria require initiating therapy among 68% of pregnant women and, if fully effective, would prevent 92% of maternal deaths and 88% of perinatal and postnatal infections. Using CD4 cell count below 350 cells/microl, irrespective of clinical stage, is more efficient and stricter CD4 cutoffs would be counter productive.

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