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Genome Biol. 2010;11(6):R62. doi: 10.1186/gb-2010-11-6-r62. Epub 2010 Jun 17.

Whole exome capture in solution with 3 Gbp of data.

Author information

1
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. bainbrid@bcm.edu

Abstract

We have developed a solution-based method for targeted DNA capture-sequencing that is directed to the complete human exome. Using this approach allows the discovery of greater than 95% of all expected heterozygous singe base variants, requires as little as 3 Gbp of raw sequence data and constitutes an effective tool for identifying rare coding alleles in large scale genomic studies.

PMID:
20565776
PMCID:
PMC2911110
DOI:
10.1186/gb-2010-11-6-r62
[Indexed for MEDLINE]
Free PMC Article

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