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J Infect Dis. 2010 Aug 15;202(3):386-91. doi: 10.1086/653705.

Intracellular Casp8p41 content is inversely associated with CD4 T cell count.

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1
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.

Abstract

Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

PMID:
20565257
PMCID:
PMC2906377
DOI:
10.1086/653705
[Indexed for MEDLINE]
Free PMC Article

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