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Atherosclerosis. 2010 Sep;212(1):339-44. doi: 10.1016/j.atherosclerosis.2010.05.032. Epub 2010 May 31.

Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women.

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School of Public Health, Curtin Health Innovation Research Institute, ATN Centre for Metabolic Fitness, Curtin University of Technology, Perth, Western Australia, Australia.



The purpose of this study was to investigate the acute effects of dietary whey proteins on lipids, glucose and insulin, and resting energy expenditure in overweight and obese post-menopausal women, a population highly susceptible to cardiovascular disease.


A three-way crossover design study was conducted where 20 overweight or obese, post-menopausal women were randomised to consume either 45 g whey protein isolate, 45 g sodium caseinate or 45 g of a glucose control in conjunction with a breakfast meal. Blood samples were taken for up to 6 h.


There was no significant change in postprandial incremental area under the curve (AUC) for total cholesterol, low density lipoprotein, high density lipoprotein, non-esterified fatty acids, Apo B48, insulin and leptin between groups. However, there was a significant decrease in the appearance of triglycerides (TG) in the blood by 21% and 27% after consuming the whey meal compared to control and casein meals, respectively, as measured by AUC. There was also a significant reduction by 27% and 32% in the AUC for TG:ApoB48 ratio in the whey group compared to the glucose and casein groups, respectively. There was a significantly lower AUC for blood glucose after the consumption of the whey and casein meal compared to glucose meal.


These findings suggest that a single dose of whey protein can decrease arterial exposure to smaller TG-enriched lipoprotein particles compared to the glucose and casein meals in the postprandial period in overweight and obese, post-menopausal women.

[Indexed for MEDLINE]

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