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Atherosclerosis. 2010 Sep;212(1):339-44. doi: 10.1016/j.atherosclerosis.2010.05.032. Epub 2010 May 31.

Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women.

Author information

1
School of Public Health, Curtin Health Innovation Research Institute, ATN Centre for Metabolic Fitness, Curtin University of Technology, Perth, Western Australia, Australia. pal@curtin.edu.au

Abstract

OBJECTIVE:

The purpose of this study was to investigate the acute effects of dietary whey proteins on lipids, glucose and insulin, and resting energy expenditure in overweight and obese post-menopausal women, a population highly susceptible to cardiovascular disease.

METHODS:

A three-way crossover design study was conducted where 20 overweight or obese, post-menopausal women were randomised to consume either 45 g whey protein isolate, 45 g sodium caseinate or 45 g of a glucose control in conjunction with a breakfast meal. Blood samples were taken for up to 6 h.

RESULTS:

There was no significant change in postprandial incremental area under the curve (AUC) for total cholesterol, low density lipoprotein, high density lipoprotein, non-esterified fatty acids, Apo B48, insulin and leptin between groups. However, there was a significant decrease in the appearance of triglycerides (TG) in the blood by 21% and 27% after consuming the whey meal compared to control and casein meals, respectively, as measured by AUC. There was also a significant reduction by 27% and 32% in the AUC for TG:ApoB48 ratio in the whey group compared to the glucose and casein groups, respectively. There was a significantly lower AUC for blood glucose after the consumption of the whey and casein meal compared to glucose meal.

CONCLUSION:

These findings suggest that a single dose of whey protein can decrease arterial exposure to smaller TG-enriched lipoprotein particles compared to the glucose and casein meals in the postprandial period in overweight and obese, post-menopausal women.

[Indexed for MEDLINE]

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