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J Sex Med. 2010 Sep;7(9):3096-103. doi: 10.1111/j.1743-6109.2010.01871.x.

Sexual desire and the female sexual function index (FSFI): a sexual desire cutpoint for clinical interpretation of the FSFI in women with and without hypoactive sexual desire disorder.

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1
New England Research Institutes, Inc., Watertown, MA 02472, USA.

Abstract

INTRODUCTION:

A validated cutpoint for the total Female Sexual Function Index scale score exists to classify women with and without sexual dysfunction. However, there is no sexual desire (SD) domain-specific cutpoint for assessing the presence of diminished desire in women with or without a sexual desire problem.

AIMS:

This article defines and validates a specific cutpoint on the SD domain for differentiating women with and without hypoactive sexual desire disorder (HSDD).

METHODS:

Eight datasets (618 women) were included in the development dataset. Four independent datasets (892 women) were used in the validation portion of the study.

MAIN OUTCOME MEASURES:

Diagnosis of HSDD was clinician-derived. Receiver-operator characteristic (ROC) curves were used to develop the cutpoint, which was confirmed in the validation dataset.

RESULTS:

The use of a diagnostic cutpoint for classifying women with SD scores of 5 or less on the SD domain as having HSDD and those with SD scores of 6 or more as not having HSDD maximized diagnostic sensitivity and specificity. In the development sample, the sensitivity and specificity for predicting HSDD (with or without other conditions) were 75% and 84%, respectively, and the corresponding sensitivity and specificity in the validation sample were 92% and 89%, respectively.

CONCLUSIONS:

These analyses support the diagnostic accuracy of the SD domain for use in future observational studies and clinical trials of HSDD.

[Indexed for MEDLINE]

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