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Acta Ophthalmol. 2012 Aug;90(5):449-55. doi: 10.1111/j.1755-3768.2010.01947.x. Epub 2010 Jun 18.

Measurement of central corneal thickness by high-resolution Scheimpflug imaging, Fourier-domain optical coherence tomography and ultrasound pachymetry.

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School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China.



To compare the repeatability and reproducibility of central corneal thickness (CCT) measurements by high-resolution (HR) rotating Scheimpflug imaging and Fourier-domain optical coherence tomography (FD-OCT). CCT measurements were compared to those determined by ultrasound pachymetry (UP).


In 35 healthy eyes, intra-observer repeatability for HR Scheimpflug (Pentacam) and FD-OCT (RTVue) systems was determined in consecutive images taken by an observer in the shortest time possible. Imaging was repeated again by a second observer to evaluate inter-observer reproducibility. The CCT measurements were compared among Scheimpflug, FD-OCT and UP images.


Mean coefficients of repeatability were 0.48% for Scheimpflug and 0.26% for FD-OCT. For Scheimpflug, the coefficient of inter-operator reproducibility was 0.87%. For FD-OCT, the coefficient of inter-operator reproducibility was 0.45%. The CCT measurements by Scheimpflug, OCT and UP images were (mean ± standard deviation) 521.7 ± 27.6 μm, 510.8 ± 28.6 μm and 516.5 ± 27.6 μm, respectively. The differences between instruments were statistically significant. The 95% limits of agreement in CCT were -0.7 to 22.5 μm for Pentacam-OCT, -13.4 to 24.0 μm for Pentacam-UP and -26.7 to 15.4 μm for OCT-UP. There was a high degree of correlation between CCT measured by all 3 methods.


Noncontact measurements of CCT with HR Scheimpflug and FD-OCT systems yielded excellent repeatability and reproducibility and can be used interchangeably. Although both devices were comparable with UP; in clinical practice, the measurements acquired by optical modalities are not directly interchangeable with UP measurements.

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