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Med Mycol. 2011 Apr;49 Suppl 1:S120-4. doi: 10.3109/13693786.2010.495139. Epub 2010 Jun 21.

Implications of hypoxic microenvironments during invasive aspergillosis.

Author information

1
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA.

Abstract

In order to cause disease, all pathogens must tolerate microenvironmental stresses encountered in vivo during infection. One microenvironmental stress that is known to occur at sites of tissue damage is hypoxia. Yet, the occurrence and impact of hypoxic microenvironments during invasive aspergillosis, caused by the mold Aspergillus fumigatus, are essentially unknown. Here, we briefly review the potential implications of hypoxic microenvironments on the Aspergillus-host interaction. We focus on three areas where hypoxia may play a role in determining the outcome of infection: fungal virulence, host immune responses, and efficacy of current antifungal drug treatments.

KEYWORDS:

Aspergillus fumigatus; Invasive Aspergillosis; antifungal drugs; fungal virulence; hypoxia

PMID:
20560863
PMCID:
PMC2951492
DOI:
10.3109/13693786.2010.495139
[Indexed for MEDLINE]
Free PMC Article

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