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J Cardiovasc Transl Res. 2009 Sep;2(3):245-50. doi: 10.1007/s12265-009-9111-z. Epub 2009 Jul 17.

Does vitamin D protect against cardiovascular disease?

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Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA.


Because of its role in maintaining bone density, vitamin D has long been recognized as critical to the health of women, a group at disproportionate risk of osteoporosis. Recent data from epidemiologic and laboratory studies suggest that vitamin D may also protect against the development of cardiovascular and other chronic diseases. Because three quarters of US women (and men) have suboptimal vitamin D status, many experts advocate increasing daily recommended intakes from 200-600 IU to at least 1,000 IU, which may indeed be a prudent strategy. However, data from large randomized clinical trials testing sufficiently high doses of this vitamin for cardiovascular disease prevention--as well as to assess the overall balance of benefits and risks of such supplementation--are needed.

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