Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Pathol. 2010 Jul;177(1):4-9. doi: 10.2353/ajpath.2010.090615. Epub 2010 Jun 17.

Atheromas feel the pressure: biomechanical stress and atherosclerosis.

Author information

1
Vanderbilt University School of Medicine, Department of Pathology, 1161 21 Ave. South. C2217A MCN, Nashville, TN 37232, USA.

Abstract

Atherosclerosis, a chronic vascular disease, is the underlying cause of over half the deaths in the United States each year. Variations in local vascular hemodynamics predispose select sites in the vasculature to atherosclerosis, and the atherosclerotic lesions, in turn alter the biomechanical functioning of the local microenvironment, the consequences of which are not well understood on a molecular level. Further progress in the field of atherosclerosis will require an understanding of the relationship between biomechanics, the tissue microenvironment, and the cellular and molecular response to these factors. This review summarizes this field, particularly within the context of the vascular smooth muscle cell.

PMID:
20558573
PMCID:
PMC2893643
DOI:
10.2353/ajpath.2010.090615
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center