Format

Send to

Choose Destination
Jpn J Clin Oncol. 2010 Nov;40(11):1046-52. doi: 10.1093/jjco/hyq098. Epub 2010 Jun 17.

CD147 and VEGF co-expression predicts prognosis in patients with acute myeloid leukemia.

Author information

1
Department of Hospital Nursing, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China. fu.xjyy@gmail.com

Abstract

OBJECTIVE:

To investigate the possible role of CD147 and vascular endothelial growth factor in progression and prognosis of acute myeloid leukemia.

METHODS:

Immunohistochemical staining was performed to detect the expression of CD147 and vascular endothelial growth factor in paraffin-embedded sections from 62 bone marrow biopsies obtained from an equal number of patients with newly diagnosed acute myeloid leukemia.

RESULTS:

CD147 and vascular endothelial growth factor expression in the bone marrow of acute myeloid leukemia patients were significantly higher than those in normal controls (both P < 0.001). Expression of them was significantly increased in patients with a high degree of microvessel density compared with those with a low degree (CD147: P = 0.009; vascular endothelial growth factor: P = 0.01) and correlated well with bone marrow microvessel density (CD147: P = 0.01; vascular endothelial growth factor: P = 0.02). In addition, higher levels of CD147 and vascular endothelial growth factor were also found in acute myeloid leukemia patients with an unfavorable karyotype compared with those with intermediate and favorable karyotypes (both P = 0.01). Moreover, the expression of CD147 was significantly correlated with that of vascular endothelial growth factor (P < 0.001). Furthermore, the co-expression of CD147 and vascular endothelial growth factor in the bone marrow indicated a poor prognosis in acute myeloid leukemia and was an independent prognostic factor for overall survival by multivariate analysis.

CONCLUSIONS:

Our data show for the first time that the co-expression of CD147 and vascular endothelial growth factor may indicate a poor prognosis in acute myeloid leukemia and may be a highly sensitive marker for predicting the clinical outcome of patients.

PMID:
20558462
DOI:
10.1093/jjco/hyq098
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center