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Transfus Apher Sci. 2010 Aug;43(1):51-9. doi: 10.1016/j.transci.2010.05.009. Epub 2010 Jun 16.

Red cell changes during storage.

Author information

1
University of Maryland School of Medicine, Baltimore, MD 21201, USA. jhess@umm.edu

Abstract

Red blood cells can be stored in liquid suspension in approved additive solutions for periods up to 6 weeks with 0.4% hemolysis, 84% 24-h in vivo recovery, and normal subsequent survival of the cells that persist in the circulation for at least 24h. However, while they are stored, the red cells undergo changes including the loss of adenosine triphosphate, diphosphoglycerate, and potassium, oxidative injury to proteins, lipids, and carbohydrates, loss of shape and membrane, increased adhesiveness, decreased flexibility, reduced capillary flow, and decreased oxygen delivery. Deaths have been reported related to the high potassium and lysophospholipids, but are rare.

PMID:
20558107
DOI:
10.1016/j.transci.2010.05.009
[Indexed for MEDLINE]

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