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J Heart Lung Transplant. 2010 Sep;29(9):1034-8. doi: 10.1016/j.healun.2010.05.007. Epub 2010 Jun 16.

Pandemic influenza (H1N1): impact on lung transplant recipients and candidates.

Author information

1
Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petach Tiqwa, Israel.

Abstract

BACKGROUND:

The year 2009 was notable for the outbreak of a novel strain of influenza A (H1N1). We report the outcomes of H1N1 infection in a large cohort of lung transplant (LTx) recipients and candidates.

METHODS:

This was a retrospective review of 22 suspected cases of H1N1 influenza screened using real-time polymerase chain reaction from nasal secretions. There were 15 confirmed cases (10 LTx recipients, 5 LTx candidates).

RESULTS:

All patients were treated with oseltamivir at the time of the first clinical assessment. In the LTx recipients group, 7 of the 10 confirmed cases were treated at home with oseltamivir alone. Three patients were admitted with complications (2 pneumonia, 1 acute rejection). Two patients required mechanical ventilation. Two patients had prolonged viral shedding. No deaths occurred among the LTx recipients. In the 5 LTx candidates with confirmed H1N1, 2 deaths occurred from pneumonia and acute respiratory distress syndrome.

CONCLUSIONS:

Influenza H1N1 had a significant complication rate amongst LTx recipients and a high mortality rate amongst LTx candidates.

PMID:
20558087
DOI:
10.1016/j.healun.2010.05.007
[Indexed for MEDLINE]
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