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J Am Chem Soc. 2010 Jul 7;132(26):8885-7. doi: 10.1021/ja1034123.

Gold-catalyzed three-component coupling: oxidative oxyarylation of alkenes.

Author information

1
Department of Chemistry, University of California, Berkeley, California 94720, USA.

Abstract

The three-component coupling of terminal alkenes with arylboronic acids and oxygen nucleophiles is described. The reaction employs a binuclear gold(I) bromide as a catalyst and Selectfluor reagent as the stoichiometric oxidant. Alcohols, carboxylic acids, and water can be employed as oxygen nucleophiles, thus providing an efficient entry into beta-aryl ethers, esters, and alcohols from alkenes.

PMID:
20557048
PMCID:
PMC2904393
DOI:
10.1021/ja1034123
[Indexed for MEDLINE]
Free PMC Article

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