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J Bioinform Comput Biol. 2010 Jun;8(3):437-51.

GH101 family of glycoside hydrolases: subfamily structure and evolutionary connections with other families.

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Laboratory of Bioinformatics, State Institute for Genetics and Selection of Industrial Microorganisms, I-Dorozhny Proezd 1, Moscow 117545, Russia.


The GH101 family is composed of endo-alpha-N-acetylgalactosaminidases and their homologues. Pairwise sequence comparison and phylogenetic analysis allowed us to distinguish five to six subfamilies in this family. Diverse domain structures were found among the family members. Usually they have five irreplaceable and some optional domains. Iterative screening of the protein database revealed an evolutionary relationship of the GH101 catalytic domain with glycoside hydrolase domains from GH13, GH31, and GH70 families. Among other homologous proteins we have found representatives of COG1649, as well as members of four new families of predicted glycoside hydrolases (GHL1-GHL4).

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