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Rev Chilena Infectol. 2010 Apr;27(2):155-9. doi: /S0716-10182010000200011. Epub 2010 May 13.

[Cryptococcal meningitis and systemic lupus erythematosus: a case report and review].

[Article in Spanish]

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Servicio de Medicina Interna, Hospital Dr. Domingo Luciani, Caracas, Venezuela.


Cryptococcal meningitis is an uncommon but well-known and frequently fatal complication of systemic lupus erythematosus (SLE). The clinical manifestations are unspecific and frequently are confused with lupus activity. A patient with cryptococcal meningitis and SLE, who responded well to amphotericin deoxycholate therapy, is reported. In a review through MEDLINE of the Spanish and English literature, 57 cases of SLE and cryptococcal meningitis were found. Simultaneous presentation of both diseases has been reported in only three cases. This temporal coexistence suggests that specific underlying immune defects associated with SLE directly predisposes to mycotic infections.

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