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Gerontology. 1991;37(1-3):152-65.

Mechanisms of protection against damage mediated by the Maillard reaction in aging.

Author information

1
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio.

Abstract

In order to prevent or escape the ongoing damage to proteins and DNA resulting from amino-carbonyl reactions, the organism has to have powerful defense mechanisms. If the Maillard reaction played a role in determining longevity among mammalian species, one would expect protective mechanisms to be more developed in long- versus short-lived species. This article summarizes current knowledge in this field, and discusses the concept of anti-Maillard mechanisms as a basis for the genetic regulation of molecular damage by reducing sugars in aging and diabetes.

PMID:
2055496
DOI:
10.1159/000213256
[Indexed for MEDLINE]

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