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Development. 2010 Aug 1;137(15):2455-60. doi: 10.1242/dev.049130. Epub 2010 Jun 16.

Shushing down the epigenetic landscape towards stem cell differentiation.

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  • 1The Howard Hughes Medical Institute, Stowers Medical Institute, Harvard Stem Cell Institute and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.


In February 2010, researchers interested in stem cell biology gathered in Keystone, Colorado, USA to discuss their findings on the origins and behaviors of pluripotent and multipotent stem cells, and their therapeutic potential. Here, we review the presentations at that meeting and the questions that emerged concerning how a stem cell ;decides' to self-renew or differentiate, what their distinct properties are and how this information can be used to develop novel therapies.

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