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Arch Neurol. 2010 Aug;67(8):961-4. doi: 10.1001/archneurol.2010.147. Epub 2010 Jun 14.

Replication of CLU, CR1, and PICALM associations with alzheimer disease.

Author information

1
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA.

Abstract

OBJECTIVE:

To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease.

DESIGN:

Follow-up case-control association study.

SETTING:

The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota.

PARTICIPANTS:

Community-based patients of European descent with late-onset Alzheimer disease (LOAD) and controls without dementia who were seen at the Mayo clinics, and autopsy-confirmed cases and controls whose pathology was evaluated at the Mayo Clinic in Jacksonville. Additional samples were obtained from the National Cell Repository for Alzheimer Disease (NCRAD). A total of 1829 LOAD cases and 2576 controls were analyzed.

INTERVENTIONS:

The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. Main Outcome Measure Clinical or pathology-confirmed diagnosis of LOAD.

RESULTS:

Odds ratios for CLU, CR1, and PICALM were 0.82, 1.15, and 0.80, respectively, comparable in direction and magnitude with those originally reported. P values were 8.6 x 10(-5), .014, and 1.3 x 10(-5), respectively; they remain significant even after Bonferroni correction for the 3 single-nucleotide polymorphisms tested.

CONCLUSION:

These results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD.

PMID:
20554627
PMCID:
PMC2919638
DOI:
10.1001/archneurol.2010.147
[Indexed for MEDLINE]
Free PMC Article

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