Format

Send to

Choose Destination
Trends Endocrinol Metab. 2010 Sep;21(9):519-28. doi: 10.1016/j.tem.2010.05.003. Epub 2010 Jun 16.

Energy balance and puberty onset: emerging role of central mTOR signaling.

Author information

1
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.

Abstract

The onset of puberty is gated by body energy reserves and nutritional cues. The adipose hormone leptin is an essential signal for the metabolic control of puberty, through mechanisms that are yet to be fully characterized. Mammalian target of rapamycin (mTOR), an energetic cell sensor, operates at specific hypothalamic nuclei as a transducer for leptin effects on feeding and energy homeostasis. This review summarizes recent experimental evidence supporting a role for central mTOR signaling in puberty onset. These findings are discussed in the context of topical developments in the field, such as recognition of the roles of the cAMP responsive element-binding protein regulated transcription coactivator-1 (Crtc1) and kisspeptins in the metabolic control of reproduction, thus highlighting novel mechanisms responsible for coupling puberty and energy homeostasis.

PMID:
20554449
DOI:
10.1016/j.tem.2010.05.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center