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Phytomedicine. 2010 Nov;17(13):993-9. doi: 10.1016/j.phymed.2010.03.014. Epub 2010 May 31.

Anti-osteoporotic constituents from Indian medicinal plants.

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Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, M. G. Road, Lucknow 226001, Uttar Pradesh, India.


The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.

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