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Mol Biochem Parasitol. 2010 Oct;173(2):162-4. doi: 10.1016/j.molbiopara.2010.05.015. Epub 2010 May 27.

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates.

Author information

1
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH Scotland, UK.

Abstract

Enhancement of the anti-oxidant metabolism of Leishmania parasites, dependent upon the unique dithiol trypanothione, has been implicated in laboratory-generated antimony resistance. Here, the role of the trypanothione-dependent anti-oxidant pathway is studied in antimony-resistant clinical isolates. Elevated levels of tryparedoxin and tryparedoxin peroxidase, key enzymes in hydroperoxide detoxification, were observed in antimonial resistant parasites resulting in an increased metabolism of peroxides. These data suggest that enhanced anti-oxidant defences may play a significant role in clinical resistance to antimonials.

PMID:
20553768
PMCID:
PMC3428625
DOI:
10.1016/j.molbiopara.2010.05.015
[Indexed for MEDLINE]
Free PMC Article

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