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Artif Cells Blood Substit Immobil Biotechnol. 2011 Feb;39(1):44-50. doi: 10.3109/10731199.2010.494580. Epub 2010 Jun 17.

Development of serratiopeptidase and metronidazole based alginate microspheres for wound healing.

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Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India.


The objective of this study was to establish an effective therapy system for wound management. The present work describes preparation of metronidazole/serratiopeptidase loaded alginate microspheres by emulsification method. In vitro characterizations like particle size analysis, % yield, % encapsulation, and in vitro release were carried out. Wound healing assessment was determined by physical, histological, and biochemical methods. Wound healing performance of experimental formulations was compared with marketed product in rabbits. Result obtained for alginate microspheres showed good loading efficiency with spherical in shape. Experimentation suggests wound healing is improved by using serratiopeptidase and metronidazole in full thickness wounds in rabbits.

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