Send to

Choose Destination
See comment in PubMed Commons below
Front Aging Neurosci. 2010 Feb 12;2:4. doi: 10.3389/neuro.24.004.2010. eCollection 2010.

KIBRA: A New Gateway to Learning and Memory?

Author information

  • 1SYGNIS Bioscience Heidelberg, Germany.


The genetic locus encoding KIBRA, a member of the WWC family of proteins, has recently been shown to be associated with human memory performance through genome-wide single nucleotide polymorphism screening. Gene expression analysis and a variety of functional studies have further indicated that such a role is biologically plausible for KIBRA. Here, we review the existing literature, illustrate connections between the different lines of evidence, and derive models based on KIBRA's function(s) in the brain that can be further tested experimentally.


Alzheimer's disease; PKCζ; cognition; cognitive impairment; genome-wide association study (GWAS); hippocampus; memory

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk