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Kidney Int. 2010 Jul;78(1):10-3. doi: 10.1038/ki.2010.112.

The sweet side of HIF.

Author information

1
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA. volker.haase@vanderbilt.edu

Abstract

Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that mediate cellular adaptation to hypoxia. Depending on the type of injury, activation of HIF signaling in renal cells may be renoprotective or promote fibrosis. Isoe and colleagues demonstrate that hyperglycemia activates HIF-1 in mesangial cells via carbohydrate response element binding protein (ChREBP), thus providing a novel link between alterations in systemic glucose homeostasis and HIF-regulated gene expression.

PMID:
20551925
PMCID:
PMC3789845
DOI:
10.1038/ki.2010.112
[Indexed for MEDLINE]
Free PMC Article

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