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J Smooth Muscle Res. 2010;46(2):119-23.

Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents.

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Laboratoire de Physiologie et Ethnopharmacologie, Macromoléculaire et Produits Naturels, Université Mohammed 1er, Faculté des Sciences.


The anti-diarrhoeal effect of aqueous extract of Rubia tinctorum L. (Rubiaceae) roots in rodents was examined. At doses 300, 600 and 800 mg/kg aqueous extract protected rats, in a dose-dependent fashion, against castor oil-induced diarrhoeal dropping by 37, 59 and 64% respectively. Furthermore, it has significantly inhibited by 41% the gastrointestinal transit of charcoal in mice at 800 mg/kg dose of extract. These data suggest that Rubia tinctorum showed antidiarrhoeal activity by inhibiting intestinal motility which was concordant with its use in traditional medicine.

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