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Nat Rev Genet. 2010 Jul;11(7):487-98. doi: 10.1038/nrg2810.

Constraints and plasticity in genome and molecular-phenome evolution.

Author information

1
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. koonin@ncbi.nlm.nih.gov

Abstract

Multiple constraints variously affect different parts of the genomes of diverse life forms. The selective pressures that shape the evolution of viral, archaeal, bacterial and eukaryotic genomes differ markedly, even among relatively closely related animal and bacterial lineages; by contrast, constraints affecting protein evolution seem to be more universal. The constraints that shape the evolution of genomes and phenomes are complemented by the plasticity and robustness of genome architecture, expression and regulation. Taken together, these findings are starting to reveal complex networks of evolutionary processes that must be integrated to attain a new synthesis of evolutionary biology.

PMID:
20548290
PMCID:
PMC3273317
DOI:
10.1038/nrg2810
[Indexed for MEDLINE]
Free PMC Article
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