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Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11987-92. doi: 10.1073/pnas.1004433107. Epub 2010 Jun 14.

Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover.

Author information

1
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Abstract

In the study of long-term memory, how memory persists is a fundamental and unresolved question. What are the molecular components of the long-lasting memory trace? Previous studies in Aplysia and Drosophila have found that a neuronal variant of a RNA-binding protein with a self-perpetuating prion-like property, cytoplasmic polyadenylation element binding protein, is required for the persistence of long-term synaptic facilitation in the snail and long-term memory in the fly. In this study, we have identified the mRNA targets of the Drosophila neuronal cytoplasmic polyadenylation element binding protein, Orb2. These Orb2 targets include genes involved in neuronal growth, synapse formation, and intriguingly, protein turnover. These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse.

PMID:
20547833
PMCID:
PMC2900709
DOI:
10.1073/pnas.1004433107
[Indexed for MEDLINE]
Free PMC Article

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