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Brain Res. 1991 Feb 1;540(1-2):311-4.

Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain.

Author information

1
Department of Pharmacology, University of Washington, Seattle.

Abstract

The effects of an acute low dose of haloperidol on neurotensin mRNA-containing cells in rat forebrain was studied using in situ hybridization histochemistry. Within 1 h of a single dose of haloperidol (0.5 mg/kg) a nearly 3-fold increase in the number of cells that express the neurotensin/neuromedin N-encoding mRNA was observed in the dorsolateral striatum. However, the number of hybridization-positive cells did not appear to be affected in the nucleus accumbens, or the septal nuclei following treatment with the neuroleptic.

PMID:
2054626
DOI:
10.1016/0006-8993(91)90526-2
[Indexed for MEDLINE]

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