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Cell Microbiol. 2010 Aug;12(8):1036-45. doi: 10.1111/j.1462-5822.2010.01492.x. Epub 2010 Jun 11.

Complement driven innate immune response to malaria: fuelling severe malarial diseases.

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McLaughlin-Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, ON, Canada.


Severe malaria remains a major cause of global mortality. The innate immune response to infection is a key determinant of malaria severity and outcome. The complement system plays a key role in initiating and augmenting innate immune responses, including inflammation, endothelial activation, opsonization and coagulation, processes which have been implicated in malaria pathogenesis. In this review, we discuss the evidence supporting a role for excessive complement activation in the pathogenesis of severe malaria.

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