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Muscle Nerve. 2010 Jul;42(1):140-3. doi: 10.1002/mus.21638.

Polyneuropathy caused by cobalt-chromium metallosis after total hip replacement.

Author information

1
Department of Neurology and Neurobiology of Aging, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan. tokuhei@med.kanazawa-u.ac.jp

Abstract

Although metal intoxication after arthroplasty causes various symptoms, polyneuropathy has never been the focus of clinical investigation. We report the case of a 56-year-old woman with metal neuropathy. She had metallosis after hip arthroplasty with a cobalt-chromium alloy prosthesis. She developed progressive sensory disturbance, hearing loss, and hypothyroidism. Sural nerve biopsy indicated axonopathy. After exchange arthroplasty, blood levels of cobalt and chromium decreased, and her symptoms improved. Cobalt or chromium can cause axonopathy.

PMID:
20544916
DOI:
10.1002/mus.21638
[Indexed for MEDLINE]
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