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Nucleosides Nucleotides Nucleic Acids. 2010 Jun;29(4-6):321-4. doi: 10.1080/15257771003741323.

Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients.

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1
Department of Internal Medicine, Teikyo University Scool of Medicine, Tokyo, Japan. ogata@med.teiko-u.ac.jp

Abstract

We have retrospectively investigated the effects of three strong statins, atorvastatin, pitavastatin, and rosuvastatin, on serum uric acid (SUA) levels. SUA levels after a few months of statin treatment were compared with those before treatment in 150 outpatients with dyslipidemia. In the atorvastatin (n = 62) and rosuvastatin (n = 45) groups, the SUA levels were reduced by 6.5% (p < 0.0001) and 3.6% (p = 0.03) respectively, but in the pitavastatin group (n = 43), the SUA level increased by 3.7% (p = 0.38). Because uric acid is considered a risk factor for cardiovascular disorders, atorvastatin or rosuvastatin treatment may be recommended when statins are used in patients at high risk for cardiovascular disorders complicated with hyperuricemia.

PMID:
20544514
DOI:
10.1080/15257771003741323
[Indexed for MEDLINE]

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