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Mol Imaging Biol. 2011 Apr;13(2):293-302. doi: 10.1007/s11307-010-0350-9.

Targeted ultrasound contrast imaging of matrix metalloproteinase-2 in ischemia-reperfusion rat model: ex vivo and in vivo studies.

Author information

1
Department of Ultrasound, Xijing Hospital, Fourth Military Med University, Xi'an, Shann Xi, China. suhaili@fmmu.edu.cn

Abstract

PURPOSE:

We hypothesized that post-myocardial ischemia-reperfusion (I/R) remodeling associated matrix metalloproteinase-2 (MMP(2)) activation could be detected by using novel MMP(2) targeted ultrasound imaging.

PROCEDURES:

We study the combination of MMP(2)-targeted microbubbles (TMB(2)) and control microbubbles with myocardium in 1 week post-I/R rats.

RESULTS:

In in vitro studies, TMB(2) significantly bound within the risk area (RA) of 1-week post-I/R myocardial sections while rare binding was observed in the control area (CA). In in vivo studies, increased focal retention of TMB(2) was observed within the RA, with the higher myocardial video intensity (RA 42.85 ± 20.12 dB versus CA 25.85 ± 13.40 dB, p < 0.01). However, there was no difference of control microbubble retention in both CA and RA.

CONCLUSIONS:

A targeted ultrasound contrast imaging approach that employs novel TMB(2) has the potential to provide a less-invasive, higher-resolution technique for in vivo localization of MMP(2) activation and tracking of MMP-mediated post-I/R remodeling.

PMID:
20544295
DOI:
10.1007/s11307-010-0350-9
[Indexed for MEDLINE]
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